Pediatric sepsis is generally considered to comprise a spectrum of disorders that result from infection by bacteria, viruses, fungi, parasites or the toxic products of these microorganisms. Early recognition and intervention improve the outcome for infants and children with conditions that lead to sepsis.
The spectrum of sepsis ranges from a microbial invasion of the bloodstream or intoxication with early signs of circulatory compromise—including tachycardia, tachypnea, peripheral vasodilation, and fever (or hypothermia)—to full-blown circulatory collapse with multiple organ dysfunction syndrome (MODS) and death (Fig. 1).
Pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS).